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Balsa Towers
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Learners work in groups to design and build a tower out of balsa wood. As a motivator, they can compete to build a tower with the highest strength-to-weight ratio.

Sticky Structures
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In this engineering/design/arts and crafts activity, learners design and build "platforms" or "bridges" that can hold weight, and test which glue makes the strongest structure.
Leaves: Designing Leaf Arrangements on a Branch
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In this hands-on activity, learners investigate the functional design of leaves on a tree.

Life Size: What's in a microbe?
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In this activity on page 3 of the PDF, learners visualize the relative size and structural differences between microbes that have the potential to cause disease.

Exploring the Nanoworld with LEGO Bricks: Probing the Structure of Materials at the Nanoscale
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In this activity (pages 17-31), learners are introduced to techniques that are used to determine the structures of solid materials.