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This is an activity (located on page 131 of the PDF) related to sleep and circadian rhythms as well as space travel.

In this activity, learners make models representing bones on Earth and bones that have been in space. They discover what happens to bones without proper exercise and nutrition.

In this activity learners observe mold growth on different types of bread by measuring and recording the growth rate.

In this activity, learners simulate what happens to a human spine in space by making Sponge Spool Spines (alternating sponge pieces and spools threaded on a pipe cleaner).

In this activity about engineering, nutrition, and physical activity, learners design and build a healthy bone model of a space explorer which is strong enough to withstand increasing amounts of weigh

In this activity, learners test the rate of ripening fruit and vegetables and use a chemical to inhibit the ripening process.

In this activity, learners experiment and collect data during a simulation of the fluid shifts experienced by astronauts' bodies in microgravity.

In this activity, learners perform 20 arm curls with cans that simulate the weight of beans on Earth versus the weights of the same number of beans on the Moon and in space.

In this activity about humans and space travel (page 1 of PDF), learners compare and contrast the behavior of a water-filled plastic bag, both outside and inside of a container of water.

In this activity (on page 142 of the PDF), learners will compare breathing rates before and after hyperventilation to explore how reduced carbon dioxide levels in the blood lower the need to breathe.

In this activity, learners discuss how life is defined and conduct a simple experiment, looking for signs of life in three different “soil” samples.

In this activity, learners predict whether a ball on Earth or a ball on the Moon bounces higher when dropped and why.

In this activity, learners create volcanoes like those they have examined on Earth and Mars through images taken by spacecraft.

In this activity, learners create channel features with flowing water, comparing their observations to real images of Mars and Earth taken by satellites/orbiters.

In this activity, learners work in pairs to measure each other's ankles with lengths of string.

In this activity, groups of four learners must complete a set of four manual tasks. The restrictions are that they must complete the tasks in a limited time while wearing garden or rubber gloves.

In this activity about the circulatory system and space travel (on page 38 of the PDF), learners use water balloons to simulate the effects of gravity and microgravity on fluid distribution in the bod

The Butterflies in Space Teacher's Guide uses "life in space" to encourage learners to conduct their own open-ended scientific investigations.