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In this activity, learners make models representing bones on Earth and bones that have been in space. They discover what happens to bones without proper exercise and nutrition.

In this activity, learners simulate what happens to a human spine in space by making Sponge Spool Spines (alternating sponge pieces and spools threaded on a pipe cleaner).

This activity (page 2 of the PDF under SciGirls Activity: Microgravity) is a full inquiry investigation into how ordinary things behave in microgravity, similar to what astronauts experience.

In this activity, learners perform 20 arm curls with cans that simulate the weight of beans on Earth versus the weights of the same number of beans on the Moon and in space.

In this activity, learners predict whether a ball on Earth or a ball on the Moon bounces higher when dropped and why.

In this activity, learners work in pairs to measure each other's ankles with lengths of string.

In this activity about the circulatory system and space travel (on page 38 of the PDF), learners use water balloons to simulate the effects of gravity and microgravity on fluid distribution in the bod

The Butterflies in Space Teacher's Guide uses "life in space" to encourage learners to conduct their own open-ended scientific investigations.