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In this activity (on page 142 of the PDF), learners will compare breathing rates before and after hyperventilation to explore how reduced carbon dioxide levels in the blood lower the need to breathe.

In this activity (on page 146 of the PDF), learners will explore the effects of increased carbon dioxide in the bloodstream.

In this activity about the human heart (on page 5 of the PDF), learners work in teams to simulate the volume of blood moved through the circulatory system by transferring liquid into--and through--a s

In this activity about the circulatory system and space travel (on page 38 of the PDF), learners use water balloons to simulate the effects of gravity and microgravity on fluid distribution in the bod