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Lean, Mean Information Machine: Using a Simple Model to Learn about Chromosomal DNA
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Learners observe a model of a cell and its chromosomal DNA made from a plastic egg and dental floss. Use this model to illustrate how much DNA is held in one cell.

Let's Clone a Mouse, Mouse, Mouse...
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Somatic Cell Nuclear Transfer (SCNT) is a cloning method that involves transferring a nucleus from a somatic cell of the individual to be cloned to an enucleated egg.

Chromosome Shuffle
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Role-playing the parts of chromosomes and centrioles, learners use large chromosome models and nylon cords (spindle fibers and cell membranes) to walk through the processes of mitosis and meiosis.

Life Size: What's in a microbe?
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In this activity on page 3 of the PDF, learners visualize the relative size and structural differences between microbes that have the potential to cause disease.

Gel Electrophoresis
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In this activity, learners simulate the process of DNA fingerprinting by using electricity to separate colored dyes.

Does Sunscreen Protect My DNA?
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In this laboratory experiment, learners explore how effectively different sunscreens protect yeast cells from damage caused by ultraviolet (UV) radiation.

Mapping Mockingbirds
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This lesson plan revolves around studying the speciation of the Galápagos mockingbirds, which are on display at the California Academy of Sciences.

Forensic Science: Hair Sample Investigation
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This activity (on page 2 of the PDF under SciGirls Activity: Forensics) is a full inquiry investigation into how hairs from a crime scene are matched to suspects.

Bird Beak Buffet
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In this classic activity, learners investigate natural selection by becoming birds foraging for food on an island.

DNA Jewelry Models
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In this activity, learners construct a model of DNA to better understand the structure of DNA and protein synthesis.

“Chips” Off the Old Block?
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In this activity, learners bake cookies by following different recipes to better understand genetic mutations. Everyone in the group bakes the same type of cookie: chocolate chip.

Gene Switches
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In this activity, learners explore how genetic switches function and the role of genetic switches in the process of evolution.

Not Just A Bag Of Beans
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In this activity, learners count and measure kidney beans to explore natural selection and variation. Learners measure the length of 50-100 beans.

Survival of the Fittest: Battling Beetles
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This guided inquiry three-part activity engages learners in thinking about the mechanism of natural selection through data collection and pattern recognition.

The Beaks of the Finches
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In this simulation, learners become birds different beak types. Learners use various tools to represent beaks to pick up seeds and place them in a petri dish.

Microarrays and Stem Cells
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In this activity, learners use microarray technology to determine which genes are turned on and off at various points in the differentiation of pluripotent stem cells on their way to becoming pancreat

Hand Biometrics Technology
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In this activity, learners explore how engineers incorporate biometric technologies into products as well as the challenges of engineers who must weigh privacy, security and other issues when designin

Born of Blood: Craft Stick Chromosomes
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In this activity, learners work in groups to match craft sticks that represent chromosomes. Learners must define critical attributes of their chromosomes as they look for matching chromosomes.

Fruity-Glows: Pictures of Health on a Microarray Canvas
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In this activity (page 12), learners apply the concepts of pixilation and pointillism to the world of biomedical science.

Reebops
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In this genetics activity, learners create imaginary creatures known as "Reebops" to explore the relationships between genes and inherited traits.