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Generations of Traits
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In this hands-on activity, learners track and record the passage of colored "pompom traits" through three generations of gingerbread people.

Pick the Risk: The Polygenic Pedigree Challenge
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In this activity, learners are challenged to track and record the passage of colored pom poms (representing genes) through generations of a family using a pedigree.

Milk Makes Me Sick: Exploration of Lactose Intolerance
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Why does milk make some people sick? In this activity learners explore this question and explore the chemistry of milk, and our bodies!

Survival of the Fittest: Variations in the Clam Species Clamys sweetus
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This guided inquiry three-part activity engages learners in thinking about the mechanism of natural selection by encouraging them to formulate questions that can be answered through scientific investi

Reading DNA
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In this activity, learners use edible models of the DNA molecule to transcribe an mRNA sequence, and then translate it into a protein.

DNA and Histone Model
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In this activity, learners construct a 3-D paper model depicting how histone, acetyl and methyl molecules control access to DNA and affect gene DNA expression.

Have Your DNA and Eat It Too
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In this activity, learners build edible models of DNA, while learning basic DNA structure and the rules of base pairing.

Survival of the Fittest: Battling Beetles
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This guided inquiry three-part activity engages learners in thinking about the mechanism of natural selection through data collection and pattern recognition.

Chromosome Models: Karyotyping
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This activity was designed for blind learners, but all types of learners can have a tactile opportunity to construct a karyotype, an organized model of an organism’s chromosomes, conveying the chromos

Onion DNA Extraction
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This laboratory exercise is designed to show learners how DNA can easily be extracted from onion cells using simple materials.

Yabba-Dabba You
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In this activity, learners explore genes and traits. Learners investigate their fingerprints and learn how to categorize them.

Scavenger Hunt: A Group Collection
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In this activity, learners are divided into teams.

Homologous Shoes?
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This "concept demonstration" provides learners with a concrete example (a pair of shoes in a classroom "cell") of what homology means.

Phylogenetics
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This activity lets learners participate in the process of reconstructing a phylogenetic tree and introduces them to several core bioinformatics concepts, particularly in relation to evolution.

The Beaks of the Finches
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In this simulation, learners become birds different beak types. Learners use various tools to represent beaks to pick up seeds and place them in a petri dish.

Wear a Chimp on Your Wrist
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Learners construct a bracelet containing two strands of beads, which represents a double strand of DNA that codes for a gene. They match beads to the bases in a section of a chimp's DNA code.

Restriction Enzyme Digestion: How does it work? Why is it useful?
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In this activity related to plant biotechnology, learners use restriction enzymes to cut up DNA from a virus called Bacteriophage λ, a process known as restriction digestion.

Yeast DNA Extraction
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This laboratory exercise is designed to show learners how DNA can easily be extracted from yeast using simple materials.

The Ladder of Life
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In this activity, learners identify the DNA base bars guanine, cytosine, thymine and adenine. Learners create a DNA model using colored paper clips to resemble these base pairs.

Mating Game
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In this game (on pages 14-21), learners explore how each human being inherits genetic traits such as eye color.