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Lean, Mean Information Machine: Using a Simple Model to Learn about Chromosomal DNA
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Learners observe a model of a cell and its chromosomal DNA made from a plastic egg and dental floss. Use this model to illustrate how much DNA is held in one cell.

DNA Modeling Activity
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Using pipe cleaners, straws, and beads, learners explore the building blocks of life by creating their own model of DNA.

Life Size: Line 'em up!
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In this activity on page 1 of the PDF, learners compare the relative sizes of biological objects (like DNA and bacteria) that can't be seen by the naked eye.

Inside DNA
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In this activity (on pages 34-39), learners make a fairly detailed model of DNA using licorice and gumdrops.

Virus Lander
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Can you avoid the body's immune system and make someone sick? Play this online game in which you go inside a human body to explore how viruses attack cells in the body.

DNA Nanotechnology
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In this activity, learners explore deoxyribonucleic acid (DNA), a nanoscale structure that occurs in nature.

Close, Closer, Closest
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In this activity, learners perform an experiment that models a chromatography-like process called electrophoresis, a process used to analyze DNA.

DNA Extraction from Wheat Germ
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DNA is the thread of life. Encoded in its genetic sequence is the information that makes each of us unique. This activity allows you to see long, stringy strands of DNA extracted from wheat germ.

Phylogenetics
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This activity lets learners participate in the process of reconstructing a phylogenetic tree and introduces them to several core bioinformatics concepts, particularly in relation to evolution.

Wear a Chimp on Your Wrist
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Learners construct a bracelet containing two strands of beads, which represents a double strand of DNA that codes for a gene. They match beads to the bases in a section of a chimp's DNA code.

Biobarcodes: Antibodies and Nanosensors
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In this activity/demo, learners investigate biobarcodes, a nanomedical technology that allows for massively parallel testing that can assist with disease diagnosis.

Make Your Own DNA
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Learners match puzzle pieces to outlines of a DNA strand. The puzzle pieces represent the four chemicals making up DNA base pairs: adenine, thymine, guanine, and cytosine.

DNA Extraction from Cheek Cells
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DNA is the thread of life. Encoded in its genetic sequence is the information that makes each of us unique.

Exploring Structures: DNA
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In this activity, learners create a necklace of wheat germ DNA. Learners add alcohol to wheat germ so that the DNA clumps together.

What Sort?
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In this activity (on pages 22-33), learners do the kind of work genetic scientists do, sorting and comparing (images of) genetic material strands called chromosomes.

Make a DNA Model
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In this activity, learners make a 3-D model of DNA using paper and toothpicks. While constructing this model, learners will explore the composition and structure of DNA.

DNA Jewelry Models
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In this activity, learners construct a model of DNA to better understand the structure of DNA and protein synthesis.

Origami DNA
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In this activity, learners create an origami model of DNA, demonstrating its double helix structure.

DNA Spooling: Isolate DNA from Onion Cells
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In this experiment, learners isolate Deoxyribonucleic Acid (DNA) from onion cells using a simple extraction procedure.

A Recipe for Traits
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In this genetics activity, learners create and decode a “DNA recipe” for a dog by randomly selecting strips of paper that represent DNA.