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Make a Shaker
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This hands-on activity shows you how to make a shaker -- a small instrument with a big sound! Fill it with beads or even pennies for a cool sound.

Pom Pom Potential
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In this kinesthetic activity, learners move pom-pom "ions" across a membrane to simulate how an action potential is propagated along an axon.
What Molecules Make the Holes in Bread?
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In this activity, learners will discover why there are holes in bread.

Water Quality and pH Levels in Aquatic Ecosystems
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In this fun and in depth hands-on experiment, learners test various liquid samples (distilled water, lemon juice, vinegar, and baking soda mixed with water) to determine their pH levels and identify e

Forensic Science: Hair Sample Investigation
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This activity (on page 2 of the PDF under SciGirls Activity: Forensics) is a full inquiry investigation into how hairs from a crime scene are matched to suspects.

Evolutionstechnik or Selection and Variation in the Egyptian Origami Bird (Avis papyrus)
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In order to examine the random nature of mutations and natural selection, learners "breed" clutches of Egyptian Origami Birds (Avis papyrus) using random number generators (dice and coins) to mutate s

Hand Battery
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In this activity about chemistry and electricity, learners form a battery by placing their hands onto plates of different metals.

What-a-cycle
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In this activity, learners act as water molecules and travel through parts of the water cycle to discover that it is more complex than just water moving from the ground to the atmosphere.

Dinosaur Footprints & Fossils
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In this activity, early learners simulate fossil prints in play dough or clay.

Mating Game
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In this game (on pages 14-21), learners explore how each human being inherits genetic traits such as eye color.

Busted by Biology
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In this two-part activity, learners will extract their own DNA from their cheek cells and learn how DNA is analyzed and used to solve crimes.

Structure of Matter: Pigment vs. Iridescence
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This is an activity (located on page 3 of the PDF under Butterfly Wings Activity) about how visible light is affected by tiny nanoscale structures, producing iridescence on butterfly wings, soap bubbl

Damsels and Dragons
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In this outdoor activity/field trip, learners conduct experiments to explore where dragonflies and damselflies perch or rest, and how the flies change behavior in reaction to other flies or fly decoys

Low-Tech Water Filter for High-Impact Clean
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In this activity, learners consider the water features they might enjoy at a community park--a pond, brook, water playground (or "sprayground"), or pool--and what happens to the water over time.

Battling for Oxygen
Working in groups, learners model the continuous destruction and creation of ozone (O3) molecules, which occur in the ozone layer.

Build a Giant Puzzle!
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In this activity, learners assemble large cubes to make nano-related images. Learners discover how different objects are related to nanoscience and nanotechnology.

Self-Portrait Silhouettes: Activity 2
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In this activity, learners make a photographic image—without a camera!

Corals and Chemistry
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In this activity, learners investigate how increased carbon dioxide (CO2) emissions from the burning of fossil fuels is changing the acidity (pH) of the ocean and affecting coral reefs and other marin

Glow Up
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In this activity, learners explore chemiluminescence and fluorescence. Learners examine 3 different solutions in regular light, in the dark with added bleach solution, and under a black light.

Dinosaur Dig
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This is an activity about dinosaurs, fossils, and the work of paleontologists. Learners use hand tools (paint brushes, scoops, and sifters) to unearth fossil specimens in tubs of birdseed.