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Lean, Mean Information Machine: Using a Simple Model to Learn about Chromosomal DNA
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Learners observe a model of a cell and its chromosomal DNA made from a plastic egg and dental floss. Use this model to illustrate how much DNA is held in one cell.

Modeling Day and Night
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In this activity (on page 1 of the PDF), learners make a "mini-globe" to investigate the causes of day and night on our planet.

How Do Viruses Recognize a Target Cell?
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This activity demonstrates the specificity of viral vectors for target cells in gene therapy delivery methods using two approaches: 1) STYROFOAM® models demonstrate viral ligand binding to receptor pr

Water Body Salinities I
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In this activity, learners investigate the different salinity levels of oceans, rivers and estuaries.

Modeling Limits to Cell Size
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This investigation provides learners with a hands-on activity that simulates the changing relationship of surface areas-to-volume for a growing cell.

Water Clean-up
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This is an activity (located on page 3 of the PDF under Water Clean-up Activity) about the use of reduction agents to decontaminate ground water.

Space Stations: Bones of Contention
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In this activity, learners make models representing bones on Earth and bones that have been in space. They discover what happens to bones without proper exercise and nutrition.

Space Stations: Sponge Spool Spine
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In this activity, learners simulate what happens to a human spine in space by making Sponge Spool Spines (alternating sponge pieces and spools threaded on a pipe cleaner).

Why Doesn’t the Ocean Freeze?
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In this activity, learners explore how salt water freezes in comparison to fresh water.

As Straight as a Pole
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In this engineering activity (page 3 of PDF), young learners investigate how a pole can be made stable by “planting” its base in the ground or adding supports to the base.

Inside DNA
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In this activity (on pages 34-39), learners make a fairly detailed model of DNA using licorice and gumdrops.

Stream Table
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In this activity, learners use aluminum trays and wooden blocks to form stream tables to investigate river formations in two different landscape scenarios.

Mars from Above: Carving Channels
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In this activity, learners create channel features with flowing water, comparing their observations to real images of Mars and Earth taken by satellites/orbiters.

Visualizing How the Vestibular System Works
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In this activity (page 59 of the PDF), learners spin and observe false eyelashes in jars of water (prepared at least 1 day ahead of time) to investigate the effects of different types of motion on the

Make a "Mummy"
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The Ancient Egyptians used a naturally-occurring salt from the banks of the Nile River, called natron, to mummify their dead.

Biodomes Engineering Design Project
In this design-based activity, learners explore environments, ecosystems, energy flow and organism interactions by creating a model biodome. Learners become engineers who create model ecosystems.

What's in Your Blood?
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Doctors often send a sample of blood to a lab, to make sure their patients are healthy.

Building a 3-D Space Maze: Escher Staircase
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In this activity (page 95 of the PDF), learners create Escher Staircase models similar to those that were used by Neurolab's Spatial Orientation Team to investigate the processing of information about

Spill Spread
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In this simulation, learners explore how ocean currents spread all kinds of pollution—including oil spills, sewage, pesticides and factory waste—far beyond where the pollution originates.

Supporting Structures
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In this activity about living things and gravity (page 5 of PDF), learners design and build an exoskeleton or an endoskeleton for an animal of their own invention.