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Modeling Day and Night
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In this activity (on page 1 of the PDF), learners make a "mini-globe" to investigate the causes of day and night on our planet.

How Do Viruses Recognize a Target Cell?
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This activity demonstrates the specificity of viral vectors for target cells in gene therapy delivery methods using two approaches: 1) STYROFOAM® models demonstrate viral ligand binding to receptor pr

Drain Game
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In this activity (on pages 36-39), learners make a model of a watershed out of paper, then run water down the mountain to simulate how rainfall and pollution affect watersheds.

Straining Out the Dirt
Learners take on the role of environmental engineers as they design water filters.

Water Clean-up
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This is an activity (located on page 3 of the PDF under Water Clean-up Activity) about the use of reduction agents to decontaminate ground water.

Space Stations: Sponge Spool Spine
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In this activity, learners simulate what happens to a human spine in space by making Sponge Spool Spines (alternating sponge pieces and spools threaded on a pipe cleaner).

Mars from Above: Carving Channels
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In this activity, learners create channel features with flowing water, comparing their observations to real images of Mars and Earth taken by satellites/orbiters.

Mermaid's Purse
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In this activity (page 2 of pdf), learners craft a model of a skate egg case and come to understand that cartilaginous fish such as sharks and shakes employ reproductive strategies that differ from th

The Watershed Connection
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In this activity, learners interact with a 3-D model of a watershed to better understand the interconnectedness of terrestrial and aquatic environments.

Build A Treetop Walkway
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Build and test a scale model of a rainforest canopy walkway.

Supporting Structures
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In this activity about living things and gravity (page 5 of PDF), learners design and build an exoskeleton or an endoskeleton for an animal of their own invention.

The Great Plankton Race
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In this activity, learners are challenged to design a planktonic organism that will neither float like a cork nor sink like a stone.

Design a Park
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In this activity, learners are invited to imagine the park of their dreams!

Modeling an HIV Particle
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This activity helps learners visualize the Human Immunodeficiency Virus (HIV) by constructing three-dimensional HIV particle models from paper.

Breathing Machine
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In this activity, learners work in teams to construct human lung models from small plastic beverage bottles and balloons.

Make a Cast of a Tyrannosaurus rex Fossil
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In this activity, learners explore dinosaur fossils by making cast models of a T. rex. First, learners read about and research how dinosaur fossils form.

Fish forms
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In this activity, learners create a three-dimensional sculpture while examining the characteristics of fish.

Slimy Cells
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In this activity, learners solidify their conceptualization of cells by building a model of a cell in a ziplock bag.

Reason for the Seasons
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In this activity (on page 6 of the PDF), learners plot the path of the sun's apparent movement across the sky on two days, with the second day occurring two or three months after the first.

Comparing Sizes of Microorganisms
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In this activity related to microbes, learners create scale models of microorganisms and compare relative sizes of common bacteria, viruses, fungi and protozoa using metric measures: meters, centimete